Lyme – The Smart Bacteria

Lyme is a very clever, highly complex bacteria. It knows how to hide and even morphs into different forms as a survival mechanism. Once the bacteria realizes it is being attacked, it can easily change its shape to another form of the bacteria, making current treatment ineffective. I learned this the hard way, as I took rocephin and only rocephin for several months, before Dr S intervened and started with a combo therapy to make my treatment more effective. This is a big reason to not be on the same antibiotic for an extended period of time. There will be drug resistance.

The fact that Lyme can turn into several different forms is one of the reasons that a combination therapy has proven to be quite effective. Attack each form, don’t give it room to change into something else or become resistant. Makes sense, right?

When I first started finding some sources about the different forms, I was surprised as there are actually many different forms. The three most common that are talked about are:


Spirochete – A spirochete is shaped like a corkscrew and is very mobile. It’s spiral, drilling motion makes it easy for them to get deep into your tissues and bones. This particular form can easily change into other forms in order to protect themselves when they are easily threatened.


Biofilm – Strength in numbers! When the spirochetes or any other forms feel threatened, they literally colonize to form a protective group or shield to protect themselves. This shield is a sticky covering, and many medications and herbs have a hard time penetrating this shield since the inner layers are unreachable by antibiotics and your immune system. Once the Lyme bacteria feels like it is safe again, they will turn back into the spirochetes and infect you all over again.
They can also protect other co-infections in your body! Those bastards!


Cyst- This is a dormant form of the bacteria, and is usually the last to treat. I know in my protocol, there is a cyst buster during the last week of treatment along with my other antibiotics. Cysts are literally spirochetes, folded inside out , forming a hard shell. These cysts are formed when where are unfavorable conditions, and can morph back into spirochetes when they feel safe again. This form can survive the worst of the worst!

A big note to all of those who are starting to feel better or are having lessening herx reactions… you might not be better! Actually, this cyst form does not cause symptoms! Your body might have a form that is drug resistant such as the cyst form. It can take months or YEARS to come out of it’s shell, no pun intended. I personally believe this is a big reason why many feel well for awhile, and then relapse or why the actual goal in healing Chronic Lyme is remission.

Then there were others! These little bastards really are crafty!

Granular – Highly resistant to antibiotics.

L-Form (Cell Wall Deficient)- It is similar to the spirochete form, only without cell walls… hence cell wall deficient. I thought that this was the same as biofilm, but was incorrect. Biofilm almost braids itself to one another, creating a cell wall, while the L-form does not have a wall. It is not very recognized. yet the symptoms are more severe autoimmune and psychiatric issues. Difficult to treat.

Pleomorphic – There are 5 or 6 types that hide in our cells.

Blebs – Blebs, not “The Biebs”, folks. I had too look twice myself. My eyes aren’t working to well these days. Haha. Anywho… this form really takes the award for craftiness. When spirochetes feel threatened, they actually take little bits of our DNA and release them into the host as a decoy (the little hosts are the blebs), and our immune system then goes after them, and not the real spirochete!  This causes our bodies to attack our own cells.


Some ways to treat these different forms, with antibiotics or the natural route……

Spirochetes respond well to : doxycycline, rocephin, omnicef, cat’s claw

Biofilm responds well to:  azithromycin, cefdinir, serraflazyme, serrapeptase, tindamax

Cyst responds well to: grapefruit seed extract, carnivora, flagyl, tindamax

Feel free to add to the list!

Once again: Disclaimer… talk to your Doctor, don’t just start taking medications without professional consult! Also, if aren’t doing a combination therapy, discuss with your doctor the possible benefits as you are attacking these buggers in each form so they have no place to hide. 🙂

Of course, have a happy and beautiful day 🙂 🙂 🙂,,,,,,

2 thoughts on “Lyme – The Smart Bacteria

  1. This is an excellent overview of the different forms of Lyme – I will definitely bookmark this post to share with others when I am trying to explain the complexities of Lyme. I had Lyme for 3 years and did finally get rid of it; my son has Lyme, bartonella, and babesia – and probably had these infections for over 5 years before we realized it and he started treatment.

    He’s been undergoing treatment for several years now and has more ahead – rotating through various treatments as you said – not only for the various forms of Lyme but also to attack all 3 infections – but he has already improved a lot and is doing great. It is a long and difficult process!

    Thanks for the great post!


    Live with CFS

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